Estudo da evoluçäo clínica de pacientes em atendimento domiciliar: análise de 100 pacientes / Clinical evolution study of home care patientes: analysis of 100 patients

No período de novembro de 1998 a dezembro de 1999 foram acompanhados 100 pacientes em atendimento domiciliar. Todos os pacientes foram incluídos no programa por apresentarem patologias crônicas que necessitam de cuidados hospitalares em seu domicílio. Foram avaliados aspectos como sexo, diagnóstico, tempo de acompanhamento, mortalidade e reinternaçöes. Após avaliaçäo dos dados concluímos que o atendimento domiciliar é uma modalidade de tratamento que auxilia no controle dos doentes com patologias crônicas, diminuindo o número e tempo de internaçöes hospitalares.

Time sequence of changes in the responsiveness of glycogen breakdown to adrenergic agonists in perfused liver of rats with insulin-induced hypoglycemia

The time-course changes of the responsiveness of glycogen breakdown to a- and Beta-adrenergic agonists during insulin-induced hypoglycemia (IIH) were investigated. Blood glucose levels were decreased prior to the alteration in the hepatic responsiveness to adrenergic agonists. The activation of hepatic glucose production and glycogenolysis by phenylephrine (2 µM) and isoproterenol (20 µM) was decreased in IIH. The changes in the responsiveness of glycogen catabolism were first observed for isoproterenol and later for phenylephrine. Hepatic ß-adrenergic receptors showed a higher degree of adrenergic desensitization than did a-receptors. Liver glycogen synthase activity, glycogen content and the catabolic effect of dibutyryl cyclic AMP (the Beta-receptor second messenger) were not affected by IIH.